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ba0001pp201 | Cell biology: osteoblasts and bone formation | ECTS2013

Primary Human Bone Cells treated with Parathyroid Hormone or Dexamethasone show Effects on micro-RNA Expression Patterns Assessed by Second Generation Sequencing

Laxman Navya , Rubin Carl-Johan , Mallmin Hans , Nilsson Olle , Tellgren-Roth Christian , Kindmark Andreas

Introduction: Micro-RNAs (miRNAs) are important post-transcriptional regulators. By binding to complementary RNA strands, they affect mRNA levels and/or mRNA translation. We have previously identified ~90 miRNAs with significant expression levels, with a subset of miRNAs exhibiting interindividual and/or gender differences in expression. In the present project, we have investigated the impact of treatment of parathyroid hormone (PTH) and dexamethasone (DEXA) on global miRNA ex...

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ba0001pp492 | Other diseases of bone and mineral metabolism | ECTS2013

Allele dependent silencing of collagen type I using small interfering RNAs targeting 3′UTR indels – a novel therapeutic approach in osteogenesis imperfecta

Lindahl Katarina , Kindmark Andreas , Laxman Navya , Astrom Eva , Rubin Carl-Johan , Ljunggren Osten

Abstract: Osteogenesis imperfecta, also known as brittle bone disease, is a heterogeneous disorder of connective tissue generally caused by dominant mutations in the genes COL1A1 and COL1A2, encoding the α1 and α2 chains of type I (pro)collagen. Symptomatic patients are usually prescribed bisphosphonates, but this treatment is neither curative nor sufficient. A promising field is gene silencing through RNA interference. In this study, small interfering RN...

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Bone Abstracts

Primary Human Bone Cells treated with Parathyroid Hormone or Dexamethasone show Effects on micro-RNA Expression Patterns Assessed by Second Generation Sequencing

Allele dependent silencing of collagen type I using small interfering RNAs targeting 3′UTR indels – a novel therapeutic approach in osteogenesis imperfecta

BiosciAbstracts